Accurately modeling the human brain to deepen our understanding of this extraordinarily complex organ has long been a central goal in neuroscience. Recent progress in stem cell biology, particularly the development of induced pluripotent stem cell (iPSC)-derived 2D and 3D systems, has opened powerful new avenues for investigating brain development and disease, as well as for identifying novel therapeutic targets.
In this workshop, we are joined by Jean-Paul Urenda (University of Southern California), who will present a multi-organoid-on-chip model designed to overcome key limitations of existing platforms in recapitulating long-range connectivity, offering exciting potential for improved disease modeling. Building on the topic of disease modeling, Dr. Veronica Astro (King Abdullah University of Science and Technology) will share her work characterizing altered development in iPSC-derived cortical organoid models of Klinefelter Syndrome.
Together, these talks will illustrate how our High-Density Microelectrode Array (HD-MEA) platforms, MaxOne and MaxTwo, provide powerful, non-invasive tools to probe these complex systems, especially in the context of development and disease. By enabling detailed analyses of morphology, maturation, connectivity, and functional dynamics, HD-MEAs deliver unprecedented insights into functional phenotyping.
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