HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip
Blandine F. Clément, Cédric Pfister, Timothy Kurer, Céline Labouesse, Dhanajay V. Deshmukh, Julian Hengsteler, Julia Lehmann, Lorenza G. Paganella, Tobias Ruff, Vilius Dranseika, Sean Weaver, Lukas Sommer, Mark W. Tibbitt, János Vörös, Christina M. Tringides
Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression
Hanan Bloomer, Savannah R. Parker, Audrey L. Pierce, Wesley Clawson, Mallory M. Caron, Thomas Gerton, Ankit Pandey, Thanh T. Le, Tolulope Adewumi, Charlotte Kuperwasser, Michael Levin, Madeleine J. Oudin
KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling
N. Dirkx, M. Kaji, E. De Vriendt, G. Carleo, F. Miceli, B. Asselbergh, P. Verstraelen, N. Zonnekein, L. Carotenuto, L. T. Dang, V. Sommers, E. Vlaemynck, L. Lagae, B. Ceulemans, P. De Jonghe, W. H. De Vos, M. Taglialatela, S. Weckhuysen
The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela
Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia
Jay English, Danny McSweeney, Jinghui Geng, Ethan Howell, Fumiko Ribbe, Matthew Hinderhofer, Lydia Proskauer, Rebecca Sebastian, Le Wang, Tal Sharf, Zhiping P. Pang, ChangHui Pak
Synchronization of visual perception within the human fovea
Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B. Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S. Cowan, Wolf Harmening, Andreas Hierlemann, Botond Roska, Felix Franke
ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG
Rameen Shah, Rohit Budhraja, Silvia Radenkovic, Graeme Preston, Alexia Tyler King, Sahar Sabry, Charlotte Bleukx, Ibrahim Shammas, Lyndsay Young, Jisha Chandran, Seul Kee Byeon, Ronald Hrstka, Doughlas Y. Smith, Nathan P. Staff, Richard Drake, Steven A. Sloan, Akhilesh Pandey, Eva Morava, Tamas Kozicz
Homophilic wiring principles underpin neuronal network topology in vitro
Danyal Akarca, Alexander WE Dunn, Philipp J Hornauer, Silvia Ronchi, Michele Fiscella, Congwei Wang, Marco Terrigno, Ravi Jagasia, Petra E Vértes, Susanna B Mierau, Ole Paulsen, Stephen J Eglen, Andreas Hierlemann, Duncan E Astle, Manuel Schröter
A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring
Kateryna Voitiuk, Spencer T. Seiler, Mirella Pessoa de Melo, Jinghui Geng, Tjitse van der Molen, Sebastian Hernandez, Hunter E. Schweiger, Jess L. Sevetson, David F. Parks, Ash Robbins, Sebastian Torres-Montoya, Drew Ehrlich, Matthew A. T. Elliott, Tal Sharf, David Haussler, Mohammed A. Mostajo-Radji, Sofie R. Salama, Mircea Teodorescu
Viktoria Haghani, Sara Mohsen Ali, Noemi Cannizzaro, Mandar M. Patil, Paula DM Sullivan, Ammara Rehamn, Ralph Green, Roy Ben-Shalom, Janine M. LaSalle, Konstantinos Zarbalis
Self-Organizing Neural Networks in Organoids Reveal Principles of Forebrain Circuit Assembly
Sebastian Hernandez, Hunter E. Schweiger, Isabel Cline, Gregory A. Kaurala, Ash Robbins, Daniel Solis, Jinghui Geng, Tjitse van der Molen, Francisco Reyes, Chinweike Norman Asogwa, Kateryna Voitiuk, Mattia Chini, Marco Rolandi, Sofie R. Salama, Bradley M. Colquitt, Tal Sharf, David Haussler, Mircea Teodorescu, Mohammed A. Mostajo-Radji
Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds
Kelly E. Carstens, Elena Gronskaya, David Jäckel, Jessica Bertoli, Kelvin Ramirez Cuevas, Julien Dorier, Shan Wang, David Lopez-Rodriguez, Timothy J. Shafer, Marie-Gabrielle Zurich, David Pamies
Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation
Luis Fernando Messore, Auguste Vadisiute, Hayley Edmead, Aleisha Durmaz, Mohammed Abuelem, Flore Chedotal, Anna Hoerder-Suabedissen, Edward Oliver Mann, Zoltán Molnár
An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour
Fernando Messore, Rajeevan Narayanan Therpurakal, Jean-Philippe Dufour, Anna Hoerder-Suabedissen, Luiz Guidi, Kim Korrell, Marissa Mueller, Mohammed Abuelem, Armin Lak, David M. Bannerman, Edward O. Mann, Zoltán Molnár
Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder
Katharina Meyer, Matthew Woodworth, Maria Carolina Bittencourt Gonçalves, Michelle Yue, Hoor AlJandal, Shad Morton, Michael Lewandowski, Ninning Liu, Eric Zigon, Patrick Fortuna, Mariana Garcia-Corral, Bogdan Budnik, George M. Church, Jenny M. Tam