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bioRxiv
|
2025
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HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip

Blandine F. Clément, Cédric Pfister, Timothy Kurer, Céline Labouesse, Dhanajay V. Deshmukh, Julian Hengsteler, Julia Lehmann, Lorenza G. Paganella, Tobias Ruff, Vilius Dranseika, Sean Weaver, Lukas Sommer, Mark W. Tibbitt, János Vörös, Christina M. Tringides
Preprint
Functional Phenotyping
Method Development
Microphysiological Systems
Organoids
MaxOne
bioRxiv
|
2025
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Triple-Negative Breast Cancer Cells Activate Sensory Neurons via TRPV1 to Drive Nerve Outgrowth and Tumor Progression

Hanan Bloomer, Savannah R. Parker, Audrey L. Pierce, Wesley Clawson, Mallory M. Caron, Thomas Gerton, Ankit Pandey, Thanh T. Le, Tolulope Adewumi, Charlotte Kuperwasser, Michael Levin, Madeleine J. Oudin
Preprint
Disease Modeling
Functional Phenotyping
Neuronal Cell Cultures
MaxOne
bioRxiv
|
2025
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KCNQ2 Loss-of-Function variants disrupt neuronal maturation via early hyperexcitability followed by maladaptive network remodeling

N. Dirkx, M. Kaji, E. De Vriendt, G. Carleo, F. Miceli, B. Asselbergh, P. Verstraelen, N. Zonnekein, L. Carotenuto, L. T. Dang, V. Sommers, E. Vlaemynck, L. Lagae, B. Ceulemans, P. De Jonghe, W. H. De Vos, M. Taglialatela, S. Weckhuysen
Preprint
Disease Modeling
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxTwo
British Journal of Pharmacology
|
2025
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The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela
Journal Article
Pharmacology & Toxicology
Neuronal Cell Cultures
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MaxTwo
bioRxiv
|
2025
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Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia

Jay English, Danny McSweeney, Jinghui Geng, Ethan Howell, Fumiko Ribbe, Matthew Hinderhofer, Lydia Proskauer, Rebecca Sebastian, Le Wang, Tal Sharf, Zhiping P. Pang, ChangHui Pak
Preprint
Disease Modeling
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxOne
Nature Neuroscience
|
2025
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Synchronization of visual perception within the human fovea

Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B. Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S. Cowan, Wolf Harmening, Andreas Hierlemann, Botond Roska, Felix Franke
Journal Article
Functional Phenotyping
Retina
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bioRxiv
|
2025
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ALG13 loss-of-function alters glycosylation, impairs neuronal maturation, and drives network hypoactivity in a cortical organoid model of CDG

Rameen Shah, Rohit Budhraja, Silvia Radenkovic, Graeme Preston, Alexia Tyler King, Sahar Sabry, Charlotte Bleukx, Ibrahim Shammas, Lyndsay Young, Jisha Chandran, Seul Kee Byeon, Ronald Hrstka, Doughlas Y. Smith, Nathan P. Staff, Richard Drake, Steven A. Sloan, Akhilesh Pandey, Eva Morava, Tamas Kozicz
Preprint
Disease Modeling
Organoids
MaxLab Live
MaxTwo
Science
|
2025
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Human neuron subtype programming via single-cell transcriptome-coupled patterning screens

Hsiu-Chuan Lin, Jasper Janssens, Benedikt Eisinger, Philipp Hornauer, Ann-Sophie Kroell, Malgorzata Santel, Maria Pascual-Garcia, Ryoko Okamoto, Kyriaki Karava, Zhisong He, Marthe Priouret, Manuel Schröter, J. Gray Camp, Barbara Treutlein
Journal Article
Functional Phenotyping
Neuronal Cell Cultures
MaxLab Live
MaxTwo
eLife
|
2025
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Homophilic wiring principles underpin neuronal network topology in vitro

Danyal Akarca, Alexander WE Dunn, Philipp J Hornauer, Silvia Ronchi, Michele Fiscella, Congwei Wang, Marco Terrigno, Ravi Jagasia, Petra E Vértes, Susanna B Mierau, Ole Paulsen, Stephen J Eglen, Andreas Hierlemann, Duncan E Astle, Manuel Schröter
Journal Article
Functional Phenotyping
Neuronal Cell Cultures
Organoids
MaxLab Live
MaxOne
MaxTwo
Frontiers in Neuroscience
|
2025
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Sensory-spinal neuron co-culture platform enables analysis of sensory-driven spinal activation

Yuki Miyahara, Kenta Shimba, Kiyoshi Kotani, Yasuhiko Jimbo
Journal Article
Microphysiological Systems
Neuronal Cell Cultures
MaxOne
Internet of Things
|
2025
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A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring

Kateryna Voitiuk, Spencer T. Seiler, Mirella Pessoa de Melo, Jinghui Geng, Tjitse van der Molen, Sebastian Hernandez, Hunter E. Schweiger, Jess L. Sevetson, David F. Parks, Ash Robbins, Sebastian Torres-Montoya, Drew Ehrlich, Matthew A. T. Elliott, Tal Sharf, David Haussler, Mohammed A. Mostajo-Radji, Sofie R. Salama, Mircea Teodorescu
Journal Article
Functional Phenotyping
Method Development
Organoids
MaxLab Live
MaxOne
Journal of Visualized Experiments (JoVE)
|
2025
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High-density Multielectrode Array Recordings of Retinal Waves Using An Electrophysiology Platform

Rishikesh Kumar Gupta, Natalie Clark, Kaylee Yeager, Alexander Fisch, Alexandre Tiriac
Journal Article
Functional Phenotyping
Method Development
Retina
MaxOne
Communications Biology
|
2025
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Drug treatment alters performance in a neural microphysiological system of information processing

Bradley Watmuff, Forough Habibollahi, Candice Desouza, Moein Khajehnejad, Alon Loeffler, Koby Baranes, Noah Poulin, Mark Kotter, Brett J. Kagan
Journal Article
Microphysiological Systems
Neurocomputing
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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An Integrated In Vitro Platform and Biophysical Modeling Approach for Studying Synaptic Transmission in Isolated Neuronal Pairs

Giulia Amos, Vaiva Vasiliauskaitė, Jens Duru, Maria Leonor Azevedo Saramago, Tim Schmid, Alexandre Suter, Ferran Cid Torren, Joël Küchler, Tobias Ruff, János Vörös, Katarina Vulić
Preprint
Microphysiological Systems
Neuronal Cell Cultures
MaxOne
Science
|
2025
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Tellurium nanowire retinal nanoprosthesis improves vision in models of blindness

Shuiyuan Wang, Chengyong Jiang, Yiye Yu, Zhenhan Zhang, Ruge Quhe, Ruyi Yang, Yufei Tian, Xindong Chen, Wenqiang Fan, Yinge Niu, Biao Yan, Chunhui Jiang, Yang Wang, Zhen Wang, Chunsen Liu, Weida Hu, Jiayi Zhang, Peng Zhou
Journal Article
Method Development
MaxOne
Biomimetics
|
2025
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Biomimetic Visual Information Spatiotemporal Encoding Method for In Vitro Biological Neural Networks

Xingchen Wang, Bo Lv, Fengzhen Tang, Yukai Wang, Bin Liu, Lianqing Liu, Xingchen Wang, Bo Lv, Fengzhen Tang, Yukai Wang, Bin Liu, Lianqing Liu
Journal Article
Neurocomputing
Neuronal Cell Cultures
MaxLab Live
MaxOne
PLOS Biology
|
2025
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Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice

Hiroyuki J. Kanaya, Ken Kuwajima, Yuko Ito, Yuta Shinohara, Yohei Okubo, Shinnosuke Shiono, Fumiya Tatsuki, Rei-ichiro Ohno, Hideki Ukai, Maki Ukai-Tadenuma, Kenta Sumiyama, Hiroshi Fujishima, Rikuhiro G. Yamada, Daisuke Tone, Hiroshi Kiyonari, Masaki Kikuchi, Takashi Umehara, Takashi Murayama, Kazunori Kanemaru, Masamitsu Iino, Koji L. Ode, Takatsugu Hirokawa, Hiroki R. Ueda
Journal Article
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxTwo
bioRxiv
|
2025
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Excess prenatal folic acid supplementation alters cortical gene expression networks and electrophysiology

Viktoria Haghani, Sara Mohsen Ali, Noemi Cannizzaro, Mandar M. Patil, Paula DM Sullivan, Ammara Rehamn, Ralph Green, Roy Ben-Shalom, Janine M. LaSalle, Konstantinos Zarbalis
Preprint
Pharmacology & Toxicology
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures

Elisa Tentori, George Kastellakis, Marta Maschietto, Alessandro Leparulo, Panayiota Poirazi, Luca Mazzucato, Michele Allegra, Stefano Vassanelli
Preprint
Method Development
Neuronal Cell Cultures
MaxLab Live
MaxOne
bioRxiv
|
2025
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Self-Organizing Neural Networks in Organoids Reveal Principles of Forebrain Circuit Assembly

Sebastian Hernandez, Hunter E. Schweiger, Isabel Cline, Gregory A. Kaurala, Ash Robbins, Daniel Solis, Jinghui Geng, Tjitse van der Molen, Francisco Reyes, Chinweike Norman Asogwa, Kateryna Voitiuk, Mattia Chini, Marco Rolandi, Sofie R. Salama, Bradley M. Colquitt, Tal Sharf, David Haussler, Mircea Teodorescu, Mohammed A. Mostajo-Radji
Preprint
Functional Phenotyping
MaxOne
Archives of Toxicology
|
2025
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Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds

Kelly E. Carstens, Elena Gronskaya, David Jäckel, Jessica Bertoli, Kelvin Ramirez Cuevas, Julien Dorier, Shan Wang, David Lopez-Rodriguez, Timothy J. Shafer, Marie-Gabrielle Zurich, David Pamies
Journal Article
Pharmacology & Toxicology
Organoids
MaxLab Live
MaxTwo
Frontiers in Neuroanatomy
|
2025
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Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation

Luis Fernando Messore, Auguste Vadisiute, Hayley Edmead, Aleisha Durmaz, Mohammed Abuelem, Flore Chedotal, Anna Hoerder-Suabedissen, Edward Oliver Mann, Zoltán Molnár
Journal Article
Functional Phenotyping
Brain Slices
MaxOne
Molecular Neurobiology
|
2025
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Spinal Cord Organoids from Human Amniotic Fluid iPSC Recapitulate the Diversity of Cell Phenotypes During Fetal Neural Tube Morphogenesis

Juan C. Biancotti, Hannah E. Moore, Anne M. Sescleifer, Shelby R. Sferra, Annalise B. Penikis, Jena L. Miller, Shaun M. Kunisaki
Journal Article
Functional Phenotyping
Organoids
MaxLab Live
MaxOne
Translational Psychiatry
|
2025
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An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour

Fernando Messore, Rajeevan Narayanan Therpurakal, Jean-Philippe Dufour, Anna Hoerder-Suabedissen, Luiz Guidi, Kim Korrell, Marissa Mueller, Mohammed Abuelem, Armin Lak, David M. Bannerman, Edward O. Mann, Zoltán Molnár
Journal Article
Disease Modeling
Functional Phenotyping
Brain Slices
MaxOne
bioRxiv
|
2025
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Altered Protein Phosphorylation in a Novel Midbrain Organoid Model for Bipolar Disorder

Katharina Meyer, Matthew Woodworth, Maria Carolina Bittencourt Gonçalves, Michelle Yue, Hoor AlJandal, Shad Morton, Michael Lewandowski, Ninning Liu, Eric Zigon, Patrick Fortuna, Mariana Garcia-Corral, Bogdan Budnik, George M. Church, Jenny M. Tam
Preprint
Disease Modeling
Organoids
MaxLab Live
MaxTwo
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