Abstract
Details
- Capture robust network activity: InSphero 3D InSight™ Human Neural Microtissues on the MaxTwo 24-Well Plate show reproducible spontaneous activity, synchronized network bursting, and high-quality extracellular signals across independent microtissues.
- Resolve compound-specific responses: MaxWell Biosystems' MaxTwo HD-MEA system scales to distinguish functional effects, with kainic acid and 4-AP enhancing neuronal and network activity while isoguvacine and TTX suppress or abolish it.
- Uncover mechanistic signatures: Advanced burst-shape analysis goes beyond conventional network metrics to show how kainic acid and 4-AP reshape burst onset, peak activity, and decay dynamics.